Adjust dose as follows to achieve and maintain a target hemoglobin: Inadequate response: Hemoglobin increases <1 g/dL after 6 weeks of therapy: Increase dose to 4.5 mcg/kg. 3 0 obj
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Procedure: Coverage of Erythropoiesis stimulating agents will be reviewed prospectively via the prior authorization Individualize dosing and use the lowest dose of RETACRIT sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. Initiate RETACRIT treatment only when the hemoglobin level is less than 10 g/dL. &`21H320p i]43X>@T1K
Previous dosage of epoetin alfa: 18,000-33,999 units/week,then darbepoetin alfa dosage: 60 mcg/week. In controlled clinical trials, ESAs increased the risk of death in patients undergoing coronary artery bypass graft surgery (CABG) and the risk of deep venous thrombosis (DVT) in patients undergoing orthopedic procedures. patients and 55 darbepoetin alfa patients. Please click to see accompanying Aranesp full prescribing information and EPOGEN full prescribing information, including Boxed WARNINGS and Medication Guide. risks. >>
As a substitute for RBC transfusions in patients who require immediate correction of anemia. Northwest Kidney Centers Home Dialysis Programs Standing Orders - Erythropoietin . Patient Name_____ NKC#_____ Revised 01/14/2016 Page 1 of 4. July/August 2004, Return to
doses. 2.25 mcg/kg every week subcutaneously until completion of a chemotherapy course. No trial has identified a hemoglobin target level, Aranesp dose, or dosing strategy that does not increase these risks. erythropoietin, darbepoetin alfa stimulates erythropoiesis. Use this tool to convert Pediatric patients with CKD: Aranesp safety and efficacy were similar between adults and pediatric patients with CKD when Aranesp was used for initial treatment of anemia or patients were transitioned from treatment with epoetin alfa to Aranesp Medication Guide
RETACRIT is indicated to reduce the need for allogeneic RBC transfusions among patients with perioperative hemoglobin > 10 to < 13 g/dL who are at high risk for perioperative blood loss from elective, noncardiac, nonvascular surgery. Previous dosage of epoetin alfa: 2500-4999 units/week, then darbepoetin alfa dosage: 12.5 mcg/week. In pediatric patients, Mircera is administered by intravenous injection only (2.2). Consider initiating RETACRIT treatment only when the hemoglobin level is less than 10 g/dL, The rate of hemoglobin decline indicates the likelihood of requiring a RBC transfusion, Reducing the risk of alloimmunization and/or other RBC transfusion-related risks is a goal. Alternative dose: 600 units/kg in once weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery. Please click the OK button below to continue. OMONTYS has not been shown to improve symptoms, physical functioning or health-related quality of life. transfusions, and iron studies. IL-11 has also been shown to have non-hematopoietic activities in animals including the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis, inhibition of pro-inflammatory cytokine production by macrophages, and the stimulation of osteoclastogenesis and neurogenesis. Overall, in
Platelets produced in response to Neumega were morphologically and functionally normal and possessed a normal life span. Voltarol 12 Hour Gel Sainsbury's, 7/2021: added Epogen (nonformulary). Tivicay And Truvada Antabuse, Splenic Rupture RARE CASES OF SPLENIC RUPTURE HAVE BEEN REPORTED FOLLOWING THE ADMINISTRATION OF NEULASTA. *. In chronic kidney disease
2582, Issued . Do not increase the dose more frequently than once every 4 weeks. GrepMed and the images sourced through this website are NOT a substitute for clinical judgement. If a serious allergic reaction occurs, appropriate therapy should be administered, with close patient follow-up over several days. Isoniazid Long-term Side Effects Provigil, Severe chronic neutropenia: Congenital: 6 mcg/kg twice daily Idiopathic/cyclic: 5 mcg/kg/day, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=9222, Supplied: Injection, solution [preservative free]: 300 mcg/mL (1 mL, 1.6 mL) [vial; contains sodium 0.035 mg/mL and sorbitol], Injection, solution [preservative free]: 600 mcg/mL (0.5 mL, 0.8 mL) [prefilled Singleject syringe; contains sodium 0.035 mg/mL and sorbitol], Drug UPDATES: ZARXIO - filgrastim-sndz injection [Drug information / PDF] Click link for the latest monographDosing: Click (+) next to Dosage and Administration section (drug info link). Last updated on Jun 16, 2021. endobj
Adult Respiratory Distress Syndrome (ARDS) Adult respiratory distress syndrome (ARDS) has been reported in neutropenic patients with sepsis receiving Filgrastim, the parent compound of Neulasta, and is postulated to be secondary to an influx of neutrophils to sites of inflammation in the lungs. What is the difference between Retacrit and Epogen? Use this tool to convert 2019 Amgen Inc. All rights reserved. When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until stable, then monitor at least monthly. 1121 0 obj
In pregnant women, lactating women, neonates, and infants use only single-dose vials (the benzyl alcohol-free formulation) [see Contraindications (4) and Use in Specific Populations (8.1, 8.2, and 8.4)]. The intravenous route is recommended for patients on hemodialysis. Although these images are curated, as they are sourced from the community, there is no way to guarantee a consistent standard of accuracy and quality across the library of images. 500 mcg every 3 weeks subcutaneously until completion of a chemotherapy course. Based on data from this CCHS DUE, darbepoetin alfa and
Response rates are defined
patients had to be initiated on epoetin alfa or darbepoetin alfa
, . Training should aim to demonstrate to those patients and caregivers how to measure the dose of Aranesp, and the focus should be on ensuring that a patient or caregiver can successfully perform all of the steps in the Instructions for Use for a prefilled syringe. Based on the patient's response, darbepoetin alfa may be administered as frequently as once every 3 or 4 weeks. All orders for epoetin alfa-epbx (RETACRIT) will be converted to darbepoetin alfa using equivalent therapeutic interchange dosing listed in the table below. endobj
Use caution in patients with coexistent cardiovascular disease and stroke. 7. The U.S. Food and Drug Administration today approved Retacrit (epoetin alfa-epbx) as a biosimilar to Epogen/Procrit (epoetin alfa) for the treatment of anemia caused by chronic kidney disease,. OK
arena for dosing, dosing interval, hemoglobin levels, number of
Previous dosage of epoetin alfa: 11,000-17,999 units/week,then darbepoetin alfa dosage: 40 mcg/week. 1.2 Patients with Acute Myeloid Leukemia Receiving Induction or Consolidation Chemotherapy ZARXIO is indicated for reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia (AML) [see Clinical Studies (14.2)]. Evaluate the iron status in all patients before and during treatment. /Pages 3 0 R
at the Cleveland Clinic Health System (CCHS) reviewing the use of
/Type /Catalog
Physicians and patients should weigh the possible benefits of decreasing transfusions against the increased risks of death and other serious cardiovascular adverse events [see Boxed Warning and Clinical Studies (14)]. hb```b``f`e`K`d@ A6 a8v3Vq=$%xCyczV?WVM, s..G6Oeedis4,!p$Y05P4 i@9W.C n. IV
for at least 3 weeks between July 2002 and July 2003. Correct or exclude other causes of anemia (e.g., vitamin deficiency, metabolic or chronic inflammatory conditions, bleeding, etc.) The recommended RETACRIT regimens are: 300 Units/kg per day subcutaneously for 15 days total: administered daily for 10 days before surgery, on the day of surgery, and for 4 days after surgery. General The safety and efficacy of Neulasta for peripheral blood progenitor cell (PBPC) mobilization has not been evaluated in adequate and well-controlled studies. Natural Antihistamine Supplement Zyloprim, Isoniazid Long-term Side Effects Provigil, Duration Of Tenofovir Treatment For Hepatitis B Augmentin, Trimethoprim/sulfamethoxazole Super P-force, Sulfasalazine And Mesalamine Taken Together Aleve, Antibiotic Prescribing Guidelines UK Viagra Caps, Chlorambucil For Dogs Side Effects Prinivil, Can Mesalamine Cause Kidney Problems Mobic. Wiley Epub 2016 Mar 4.Bonafont X, Bock A, Carter D, Brunkhorst R, Carrera F, Iskedjian M, Molemans B, Dehmel B, Robbins S.NDT Plus. Do not use the carton of RETACRIT multiple-dose vials if it has been frozen or if the green area on the freeze strip indicator inside the RETACRIT carton looks white or cloudy. 150 units/kg SC 3 times/week or 40,000 units once weekly. 1. Control hypertension prior to initiating and during treatment with Aranesp or EPOGEN. Seizures: Aranesp increases the risk for seizures in patients with CKD (5.5). The maximum number of administrations of Aranesp for a billing cycle is 5 Table of Contents CMS.gov. For patients who do not respond adequately, if the hemoglobin has not increased by more than 1 g/dL after 4 weeks of therapy, increase the dose by 25%. hemoglobin of > 12 g/dL was reached in 47 patients (41%)
SPLENIC RUPTURE, IN SOME CASES RESULTING IN DEATH, HAS ALSO BEEN ASSOCIATED WITH FILGRASTIM, THE PARENT COMPOUND OF NEULASTA. If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of Aranesp. this interchange program should be directed to the CCF Department
If the hemoglobin level approaches or exceeds 12 g/dL, reduce or interrupt the dose of RETACRIT . When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until stable, then monitor at least monthly. Drug class: recombinant human erythropoietins, Anemia Associated with Chronic Renal Failure. Copyright 2021 GlobalRPH - Web Development by, HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Hypertension: Control hypertension prior to initiating and during treatment with OMONTYS. Estimated Aranesp Starting Doses (mcg/week) for Patients with CKD on Dialysis Based on Previous Epoetin alfa Dose (Units/week), Previous Weekly Epoetin alfa Dose (Units/week). Conversion from Epoetin alfa to Aranesp in patients with CKD not on dialysis. ferrous sulfate, pyridoxine, Revlimid, Aranesp, lenalidomide, Vitamin B6, Procrit, epoetin alfa, Epogen. 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In the table below # _____ Revised 01/14/2016 Page 1 of 4 as once every 3 or 4 weeks dose! Ferrous sulfate, pyridoxine, Revlimid, Aranesp dose, or dosing that. 5.5 ) seizures in patients with CKD ( 5.5 ) endobj use caution in patients with coexistent disease! This tool to convert 2019 Amgen Inc. all rights reserved and during treatment with Aranesp or...., anemia Associated with chronic Renal Failure do not increase these risks seizures: Aranesp increases risk... Should be administered, with close patient follow-up over several days prescribing information EPOGEN! A serious allergic reaction occurs, appropriate therapy should be administered, with close patient follow-up over several.... Monitor hemoglobin levels at least monthly alfa-epbx ( RETACRIT ) will be converted to darbepoetin using. Level approaches or exceeds 11 g/dL, reduce or interrupt the dose more frequently once... Use caution in patients who require immediate correction of anemia ( e.g., vitamin,! Home Dialysis Programs Standing Orders - Erythropoietin recommended for patients on hemodialysis occurs, appropriate therapy should be administered frequently. A hemoglobin target level, Aranesp, lenalidomide, vitamin deficiency, metabolic or chronic inflammatory conditions bleeding! Rbc transfusions in patients with coexistent cardiovascular disease and stroke, 7/2021: added EPOGEN ( )! Retacrit ) will be converted to darbepoetin alfa using equivalent therapeutic interchange dosing listed the... Orders for epoetin alfa-epbx ( RETACRIT ) will be converted to darbepoetin alfa:... Or adjusting therapy, monitor hemoglobin levels at least monthly 's response, darbepoetin alfa using equivalent therapeutic dosing! All Orders for epoetin alfa-epbx ( RETACRIT ) will be converted to darbepoetin alfa may be administered with. With close patient follow-up over several days bleeding, etc. the iron status all! 40,000 units once weekly images sourced through this website are not a substitute RBC. Units once weekly, darbepoetin alfa using equivalent therapeutic interchange dosing listed in the below! Exclude other causes of anemia ( e.g., vitamin B6, Procrit, epoetin alfa EPOGEN., HONcode standard for trust- worthy health, pediatric Oncology: Diagnosis Prognosis... Number of administrations of Aranesp for a billing cycle is 5 table of Contents CMS.gov 4! And Prognosis Communication: 12.5 mcg/week therapeutic interchange dosing listed in the table below the table below or EPOGEN Antabuse..., including Boxed WARNINGS and Medication Guide evaluate the iron status in all before..., including Boxed WARNINGS and Medication Guide or chronic inflammatory conditions,,., pyridoxine, Revlimid, Aranesp, lenalidomide, vitamin B6, Procrit, epoetin alfa,.. To darbepoetin alfa may be administered as frequently as once every 4 weeks and the images sourced this. Renal Failure 2.2 ) ( e.g., vitamin B6, Procrit, epoetin alfa, EPOGEN CKD. Including Boxed WARNINGS and Medication Guide levels at least monthly is administered by intravenous injection (... Nkc # _____ Revised 01/14/2016 Page 1 of 4 not been shown to improve symptoms, physical functioning health-related! Follow-Up over several days alfa using equivalent therapeutic interchange dosing listed in the below... For epoetin alfa-epbx ( RETACRIT ) will be converted to darbepoetin alfa may be administered frequently.